PEI HUVEC-characterization study
ELU-4-4238C7-1

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Within a broad characterization study, we analyzed activation, viability, cytokine secretion, and permeability of human umbilical vein endothelial cells (HUVECs) upon stimulation with different stimuli. In addition HUVEC-permeability was analyzed in a trans-well-based leakage assay upon stimulation in presence or absence of human peripheral blood mononuclear cells (PBMCs).

Project

Project Title: Immune safety avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies
Project website: https://www.imi.europa.eu/projects-results/project-factsheets/imsavar

Datasets

PEI - HUVEC-characterization data

Study description

Primary Purpose: Characterization study of HUVECs
Study Types: In vitro study
Description of Cohorts: This study is no clinical or cohort study. Primary human material derived from buffy coats (commercially available) or umbilical chords (cooperation) from healthy donors are used.
Informed Consent Given?: -
Multi-center Study?: -