Upper airway gene expression is an effective surrogate biomarker for Th2-driven inflammation in the lower airway
Upper airway (nasal) and lower airway (bronchial) epithelial brushings obtained from a cohort of 54 allergic asthmatics and 30 matched healthy controls were profiled by gene expression by microarray. Subjects were assayed for gene expression, serum total IgE, blood eosinophils and serum periostin.
- Primary Purpose
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- Description of Cohorts
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- Informed Consent Given?
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- Multi-center Study?
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- Organisms
- Homo sapiens
- Number of subjects
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- Diseases
- asthma
- Sample Sources
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- Type of Samples Collected
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