Transcriptional response to hypoxia of normal and rheumatoid arthritis synovial fibroblasts
Synovial fibroblasts obtained from 6 patients with rheumatoid arthritis (RASF) and 6 sex and age matched adult healthy donors (HSF) were used. SF cultures were incubated for 22 hours under normoxic or hypoxic (0.5% O2) conditions. Nine experiments per group were performed, single experiments with three SF lines, and duplicated in other three lines per group. All 18 normoxia-hypoxia experiments (36 microarray data) were used for paired analysis of the changes induced by hypoxia in HSF or RASF.
- Primary Purpose
- -
- Description of Cohorts
- -
- Informed Consent Given?
- -
- Multi-center Study?
- -
- Organisms
- Homo sapiens
- Number of subjects
- -
- Diseases
- rheumatoid arthritis
- Sample Sources
- -
- Type of Samples Collected
- -