Expression data from intestinal mucosa of patients with UC
Ulcerative colitis patients and non-inflammatory controls were collected for RNA extraction and hybridization on Affymetrix microarrays. Inclusion criteria for UC patients were: age between 18 and 65, diagnosis of UC established at least 6 months before inclusion and exclusion of concomitant infection. Active disease was defined by endoscopic and histologic score: Mayo sub score >=2 and MATTS >=3 respectively . Inactive disease was also defined by endoscopic and histologic score: Mayo sub score =0 and MATTS <=2 respectively, and a remission state for a minimum of 5 month prior to biopsy collection, and remained inactive for at least 6 months after. Uninvolved mucosa from patients with active UC was defined as a colonic segment with completely normal endoscopic appearance, normal histology, and absence of any previous evidence of active disease. Finally, a total of 43 biopsies were analyzed: 13 healthy controls, 8 inactive UC, 7 non-involved active UC and 15 involved active UC.
- Project Title
- Expression data from intestinal mucosa of patients with UC
- Project website
- https://www.ncbi.nlm.nih.gov/bioproject/PRJNA168492
- Primary Purpose
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- Description of Cohorts
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- Informed Consent Given?
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- Multi-center Study?
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- Organisms
- Homo sapiens
- Number of subjects
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- Diseases
- inflammatory bowel disease
- Sample Sources
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- Type of Samples Collected
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