Bruton's Tyrosine Kinase Regulates TLR9 but not TLR7 Signaling in Human pDCs

pDCs from healthy donors (n=4) were treated with gardiquimod (TLR7 agonist) or ODN 2216 (TLR9 agonist) with or without BTK inhibitor for 3 hours.


Primary Purpose
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Description of Cohorts
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Informed Consent Given?
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Multi-center Study?
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Organisms
Homo sapiens
Number of subjects
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Diseases
systemic lupus erythematosus
Sample Sources
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Type of Samples Collected
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Age Range of Study Participants
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BMI Range of Study Participants
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