Type I Interferon: Potential Therapeutic Target for Psoriasis?
We observed robust overexpression of type I interferon (IFN)–inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dendritic cells and 2 type I IFN–inducible proteins, STAT1 and ISG15, were observed in the majority of lesional skin biopsies. Concordant overexpression of IFN-c and TNF-a–inducible gene signatures occurred at the same disease sites.
keywords: Affymetrix Human Genome U133 Plus 2.0 array expression profiling by array
- Project website
- https://www.ncbi.nlm.nih.gov/bioproject/PRJNA112007
- Start date
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- End date
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- Funding
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- Types
- NCBI GEO
- Project publications
- https://pubmed.ncbi.nlm.nih.gov/18648529
