A global transcriptome analysis of keratinocytes upon suppression of endogenous microRNA-31

MiR-31 is one of the most highly overexpressed miRNAs in psoriasis skin; however, its biological role in the disease has not been studied. Here we show that miR-31 is markedly overexpressed in psoriasis keratinocytes. To study the biological role of miR-31 in keratinocytes, we transfected miR-31 hairpin inhibitor (anti-miR-31) into primary human keratinocytes to inhibit endogenous miR-31. We performed a global transcriptome analysis of keratinocytes upon suppression of endogenous miR-31 using Affymetrix arrays.

keywords: NCBI GEO expression profiling by array

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Ning Xu
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Karolinska Institutet
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CMM L8:02,Stockholm,17176,Sweden
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