T helper lymphocyte- and monocyte-specific type I interferon (IFN) signatures in autoimmunity and viral infection.

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This study demonstrates quantitative and qualitative differences between type I IFN signatures in autoimmunity and viral infection using purified CD4pos T cells and CD16pos- and CD16neg-monocyte subsets. We were able to discriminate between cell-specific viral response signatures and the pathogenically amplified IFN signatures observed in autoimmunity. The differences were of both a qualitative and quantitative nature, as the signatures in the patients with SLE were characterized by much more complexly compiled gene patterns with increased absolute gene expression levels.

keywords: NCBI GEO expression profiling by array

General Project Information

Project website: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA226024
Start date: -
End date: -
Funding: -
Types: NCBI GEO
Project publications: https://pubmed.ncbi.nlm.nih.gov/24391825 https://pubmed.ncbi.nlm.nih.gov/19265543

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Studies and datasets

Study	Datasets
T helper lymphocyte- and monocyte-specific type I interferon (IFN) signatures in autoimmunity and viral infection.	T helper lymphocyte- and monocyte-specific type I interferon (IFN) signatures in autoimmunity and viral infection.