Genome-Wide Profiling of Airway Epithelial Cells in Asthmatics, Smokers and Healthy Controls

We collected airway epithelial brushings for microarray analysis from 42 asthmatics and two control groups – 28 healthy subjects and 16 smokers. A subgroup of 32 asthmatics completed a randomized placebo-controlled trial of fluticasone propionate in which collection of brushings was repeated after 1 week of treatment.

keywords: disease state analysis clinical trial expression profiling by array