Rat exposure to RDX (3mg/kg or 18mg/kg; 0, 4, 24, 48 hr)
RDX (Hexahydro-1,3,5-trinitro-1,3,5-triazine) is a synthetic, high-impact, relatively stable explosive that has been in use since WWII. Exposure to RDX can occur either occupationally or through ordnance that lays unexploded on training ranges. The toxicology of RDX is dominated by acute tonic-clonic seizures at high doses, which remit when exposure is removed and internal RDX levels decrease. Sub-chronic studies have revealed few other toxic effects. The objective of this study was to examine the effect of a single oral dose of RDX on global gene expression in the mammalian brain and liver, using a rodent model.
keywords: time course dose response expression profiling by array
- Project website
- https://www.ncbi.nlm.nih.gov/bioproject/PRJNA113417
- Start date
- -
- End date
- -
- Types
- NCBI GEO
- Project publications
- https://pubmed.ncbi.nlm.nih.gov/19239275
- Main contact
- James F Dillman
- james.f.dillman2.civ@mail.mil
- Affiliation
- U.S. Army Medical Research Institute of Chemical Defense
- Business Address
- 3100 Ricketts Point Rd,Aberdeen Proving Ground,MD,21010-5400,USA
- Business Phone Number
- 4104361723
