Differential effects of TNFalpha and IL1beta on FLS global gene expression profile

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TNFalpha and IL1beta play a pathogenic role in rheumatoid arthritis. Both cytokines are known to activate cytokine and metalloproteinase secretion by synovial fibroblasts. In the present study, we wanted to investigate whether TNFalpha and IL1beta displayed differential effects on cultured Fibroblast-like Synovial Cells derived from RA patients. Global gene expression analyses indicated that both cytokines induced similar genes in these cells.

keywords: NCBI GEO expression profiling by array

General Project Information

Project website: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA116697
Start date: -
End date: -
Funding: -
Types: NCBI GEO
Project publications: https://pubmed.ncbi.nlm.nih.gov/19389237

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Studies and datasets

Study	Datasets
Differential effects of TNFalpha and IL1beta on FLS global gene expression profile	Differential effects of TNFalpha and IL1beta on FLS global gene expression profile