Transcriptional Response of Human Microglial Cells to Interferon-gamma
Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed a series of experiments to acertain the transcriptional profile of human fetal microglial cells at 1, 6, and 24 h after IFN-gamma treatment. Primary human microglial cells were either untreated or treated with 200u/ml IFN-gamma. Affymetrix U133A chips were utilized. Four different tissue samples (B18, O, W, and Y20) were analyzed at the three time points.
keywords: time-course microglia interferon-gamma macrophages expression profiling by array
- Project website
- https://www.ncbi.nlm.nih.gov/bioproject/PRJNA89967
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- NCBI GEO
- Project publications
- https://pubmed.ncbi.nlm.nih.gov/16163375