Differential gene expression in RA synovial biopsies from responders versus non-responders to adalimumab therapy

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TNF antagonists are routinely used in severe rheumatoid arthritis (RA) patients who failed conventional DMARD therapy. According to large clinical trials, the three available drugs (adalimumab, infliximab and etanercept) display similar effects in terms of efficacy, tolerability and side effects. These studies also indicate that about 25% of RA patients treated with TNF-antagonists do not display any significant clinical improvement.The aim of this study was to investigate global molecular patterns in synovial biopsies from RA patients obtained 12 weeks after initiation of adalimumab therapy.

keywords: NCBI GEO expression profiling by array

General Project Information

Project website: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA115725
Start date: -
End date: -
Funding: -
Types: NCBI GEO
Project publications: https://pubmed.ncbi.nlm.nih.gov/19389237

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Studies and datasets

Study	Datasets
Differential gene expression in RA synovial biopsies from responders versus non-responders to adalimumab therapy	Differential gene expression in RA synovial biopsies from responders versus non-responders to adalimumab therapy