AETIONOMY prospective study

Organising mechanistic knowledge about neurodegenerative diseases for the improvement of drug development and therapy

groups: IMI Projects

tags: IMI Translational Medicine

First Name
Jean-Christophe
Last Name
Corvol
Affiliation
ICM Paris
Email
jean-christophe.corvol@psl.aphp.fr
Business Phone Number
-
Business Fax Number
-
Business Address
-
Project Website
http://www.aetionomy.eu
Version
-
Date of creation of the dataset
2017-01-19
Date of the last update of the dataset
2017-01-19
Funding
IMI
Reference Publications
-
Data Standards Implemented
CDISC
Therapeutic Area Standards (Disease Area)
-
Study Protocal Description
http://www.aetionomy.eu/content/dam/scai/AETIONOMY/Dokumente/Aetionomy_Newsletter4_web.pdf
Multi-center Study
True
Description of Cohorts
http://www.aetionomy.eu/content/dam/scai/AETIONOMY/Dokumente/Aetionomy_Newsletter4_web.pdf
Study Type
OBSERVATIONAL
Study Type Comment
-
Primary Purpose
To validate the disease taxonomies proposed by the AETIONOMY project
Study Phase
Recruitment
Intervention Model
-
Study Classification
-
Indication
-
Age Range (Low Limit) of Study
-
Age Range (Upper Limit) of Study
-
Age Unit (of the above ranges)
Year
BMI Range
-
BMI Range (lower limit)
-
BMI Range (upper limit)
-
Informed Consent
True
Planned Arm (Description of Sub-cohorts)
A) PD groups (n=325): Idiopathic PD (n=240), Genetic PD with mutation in Parkin, LRRK2 or GBA (n=40), Subject at risk of PD: first degree relatives or iRBD (n=45). B) AD groups (n=150): MCI/Prodromal AD (n=90), preclinical AD (n=60), Healthy C) Controls (n=180): 90 matching PD, 90 matching AD.
Name of Treatment
-
Standardized Name of Treatment
-
Category
-
Dose Description
-
Organism
Homo sapiens
Body System or Organ Class
Brain (For the imaging data)
Total Number of (Human) Subjects
655
Total Number of (Non-Human) Subjects
655
Number of Subjects in Each Cohorts (if multi-cohorts)
-
Detail Subject Composition
-
Type of Samples Collected
Blood CSF Fibroblasts
Number of Samples Collected
-
Samples Details
-
Secondary Analysis
Transcriptome array