Search studies

Human keratinocytes stimulated with IL-17C

Human keratinocytes, HEKn, were incubated in the absence (n = 3) and presence (n = 5) of 500 ng/ml recombinant human IL-17C for 3 and 24 hours. Whole RNA was isolated via RNeasy kit (Qiagen).

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IL-1 treatment of human epidermal keratinocytes

keratinocytes were treated with 25 ng/ml IL-1 and transcriptomes compared to untreated controls at 1, 4, 24 and 48 h post treatment.

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IL-17A is an essential cytokine to sustain pathogeni...

In a phase 1, randomized, double-blind, placebo-controlled dose escalation trial, patients with chronic psoriasis were randomized to receive 3 doses of subcutaneous LY2439821 at 5 mg (n=8), 15 mg (n=8), 50 mg (n=8), 150 mg (n=8) or placebo (n=8) at weeks 0, 2 and 4. Repeat biopsies were taken from the same lesional area at baseline, week 2 and 6. At week 6, a PASI75 was observed in 0/8, 2/8, 5/7 and 8/8 patients receiving 5 mg, 15 mg, 50 mg or 150 mg LY2439821 respectively and 0/8 patients re...

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Identification and characterization of small molecul...

samples were taken from duplicate treatments of cells with DMSO or PP-2 (compound 9) at various time points

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P2N ADPSOKO

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Post-therapeutic relapse of psoriasis associated wit...

To determine the transcsriptome of skin samples in 4 responding patients who relapsed after receiving efalizumab for treatment of psoriasis, using paired baseline non-lesional (=NL, n=2); lesional (LS, n=4);week 12 post-treatment (week 12, n=4), and relapse (n=4).

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Reversal of Atopic Dermatitis with Narrow-Band UVB P...

genomic profiling of treatment effect of NB-UVB in AD in both lesional and non-lesional AD skin from 10 patients.Treatment effect , disease state analysis

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TREM-1 is a novel therapeutic target in Psoriasis

Monocytes were isolated by plastic adherence, treated with TLR agonists overnight, washed twice and harvested in RTL-buffer. RNA was extracted and processed for microarray.3 groups and 3 replicates with a paired structure across replicates

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