Search projects
30 projects found
INNODIA HARVEST
Translational approaches to disease modifying therapy of type 1 diabetes - HARVESTing the fruits of INNODIA
Keywords: IMI projects Diabetes & metabolic disorders Clinical trial design Conducting clinical trials Disease taxonomy
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SYSCID
A Systems medicine approach to chronic inflammatory diseases
Keywords: H2020 chronic inflammatory disease systems medecine
10
eTOX
Integrating bioinformatics and chemoinformatics approaches for the development of Expert systems allowing the in silico prediction of toxicities
Keywords: IMI projects Tools for predicting/monitoring efficacy 3Rs - animal use in research
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Integrated Network and Microarray Analysis to Identi...
A significant proportion of acute myocardial infarction (MI) patients develop heart failure (HF). Early identification of patients at risk of developing HF after MI would be a major breakthrough. An approach combining the power of biological information networks and the precision of microarray analysis was undertaken to identify biomarkers of HF. A set of three new biomarkers of HF was identified and provided significantly improved prediction accuracy than microarray or network analysis alone...
Keywords: NCBI GEO expression profiling by array
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Gene expression alterations in the cerebellum and gr...
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized the cystatin B deficient mice (Cstb-/-), a model for the disease. We have characterized the gene expression changes from the cerebellum of Cstb-/- mouse at postnatal day 7 (P7) and P30 as well as i...
Keywords: NCBI GEO expression profiling by array
13
B cell signature during inactive systemic lupus
Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the development of SLE which is characterized by the production of a large variety of autoantibodies and hypergammaglobulinemia. In mice, immature B cells from spontaneous lupus prone animals are able to produce autoantibodies when transferred into immunodeficient mice, strongly suggesting the existence of intrinsic B cell defects during lupus. ...
Keywords: NCBI GEO expression profiling by array
14
Transcriptome from circulating cells suggests dysreg...
Whole-genome gene expression analysis has been successfully utilized to diagnose, prognosticate, and identify potential therapeutic targets for cardiovascular disease. However, the utility of this approach to identify outcome-related genes and dysregulated pathways following first-time myocardial infarction (AMI) remains unknown and may offer a novel strategy to detect affected expressome networks that predict long-term outcome. Whole-genome microarray and targeted cytokine expression profil...
Keywords: NCBI GEO expression profiling by array
15
Test project - Methods for systematic next generatio...
The goal of OncoTrack was to identify and characterize biological markers that will help our understanding of the variable make-up of tumours and how this affects the way patients respond to treatment. Cutting edge laboratory-based genome sequencing techniques coupled to novel computer modelling approaches were used to study both the biological heterogeneity of colon cancers (i.e. patient to patient variability) as well as tumour variation within the patient – for example, by comparing primar...
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