A global transcriptome analysis of keratinocytes upon suppression of endogenous microRNA-31
MiR-31 is one of the most highly overexpressed miRNAs in psoriasis skin; however, its biological role in the disease has not been studied. Here we show that miR-31 is markedly overexpressed in psoriasis keratinocytes. To study the biological role of miR-31 in keratinocytes, we transfected miR-31 hairpin inhibitor (anti-miR-31) into primary human keratinocytes to inhibit endogenous miR-31. We performed a global transcriptome analysis of keratinocytes upon suppression of endogenous miR-31 using Affymetrix arrays.
keywords: NCBI GEO expression profiling by array
- Project website
- https://www.ncbi.nlm.nih.gov/bioproject/PRJNA178462
- Start date
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- End date
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- Funding
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- Types
- NCBI GEO
- Project publications
- https://pubmed.ncbi.nlm.nih.gov/23233723