B cell signature during inactive systemic lupus
Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the development of SLE which is characterized by the production of a large variety of autoantibodies and hypergammaglobulinemia. In mice, immature B cells from spontaneous lupus prone animals are able to produce autoantibodies when transferred into immunodeficient mice, strongly suggesting the existence of intrinsic B cell defects during lupus. In order to approach these defects in humans, we compared the peripheral B cell transcriptomes of quiescent lupus patients to normal B cell transcriptomes.
keywords: NCBI GEO expression profiling by array
- Project website
- https://www.ncbi.nlm.nih.gov/bioproject/PRJNA143913
- Start date
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- End date
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- Funding
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- Types
- NCBI GEO
- Project publications
- https://pubmed.ncbi.nlm.nih.gov/21886837 https://pubmed.ncbi.nlm.nih.gov/23109291